Electrophoretic deposition (EPD) is becoming the technique of choice to deposit a variety of functional composite coatings with biological activity. In particular biopolymer-bioactive glass composite coatings incorporating biomolecules or therapeutic drugs (e.g. antibiotics) can be obtained by EPD from aqueous suspensions. In this presentation, the application of EPD on a variety of metals of relevant biomedical applications such as stainless steel, Ti alloys and Mg / Mg alloys will be presented and discussed highlighting the advantages of the technique in comparison with other coating methods. A variety of bioactive and antibacterial coatings will be covered, in most cases involving a biodegradable natural polymer such as alginate, chitosan and inorganic fillers such as bioactive glass particles, but also carbon nanotubes and graphene oxide. It will be shown that by careful selection of the processing parameters robust coatings with high adhesion to the substrate can be obtained which provide a suitable interface for applications in the medical field, for example orthopaedics. Moreover, EPD technique can be adapted for deposition of antibacterial coatings using antibiotics (e.g. tetracycline). The obtained results confirmed that the EPD technique is a useful, cost-effective and versatile process to deposit biocompatible, bioactive and anti-microbial coatings with local drug delivery capability on metallic substrates, including those with porous or complex geometry.